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MessagePosté le: Jeu 1 Sep - 00:27 (2016)    Sujet du message: Vitamin K Deficiency Disease Pdf Download Répondre en citant

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Vitamin K Deficiency Disease Pdf Download

[PubMed]3. A poor vitamin K status is, therefore, currently regarded as a risk factor not only for bleeding, but also for increased postmenopausal bone loss and arterial calcification, especially in diabetics and in patients with chronic renal disease.The pivotal importance of vitamin K in haemostasis arises from the fact that all vitamin K-dependent coagulation factors require γ-carboxylation of glutamic acid residues at their Gla domains to enable binding of calcium and attachment to phospholipid membranes. doi:10.1097/MOL.0b013e3282f1c57f. 403 Forbidden .. The liver, moreover, contains a larger pool of vitamin K2 (90% of total liver vitamin K stores) which, therefore, represents a reservoir against vitamin deficiency when the more labile vitamin K1 stores are depleted.

(Consumption of the mother's milk can undo this temporary problem.) Another at-risk population comprises those individuals on any sort of long-term antibiotic therapy, as this can diminish the population of normal gut flora.[citation needed]. [PubMed]21. Kumar D, Greer FR, Super DM, Suttie JW, Moore JJ. The main exogenous source of vitamin K in neonates, which is almost exclusively milk, cannot adequately compensate for deficient endogenous production, since human breast milk contains between 1 and 4 μg/L of vitamin K1 (and a much lower concentration of vitamin K2).As in other circumstances in science and medicine, there is an apparent paradox in haemostasis in neonates in that prolonged global coagulation tests (i.e., activated partial thromboplastin time and prothrombin time) do not translate into a particular bleeding phenotype. PMC3321262. PMID12837888. In another study, by Costakos et al., preterm neonates who were given 0.5 to 1 mg vitamin K prophylaxis also showed vitamin K levels that were 1,900 to 2,600 times higher (2 days afterwards) and 550 to 600 times higher (10 days afterwards) than normal adult plasma values (0.5 ng/mL)36.

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